Dr. Amandine Guérinot

Dr. Amandine Guérinot
Maître de Conférences - Associate Professor
Ecole Supérieure de Physique et de Chimie Industrielles de la ville de Paris - ESPCI Paris
Department C3M: "Molecular, Macromolecular and Material Chemistry"
Team CMC: "Molecular Chemistry and Catalysis"
10 rue Vauquelin 75005 Paris
amandine.guerinot@espci.fr

Research topics

Key words: homogeneous catalysis – abundant metals – cross-coupling – photocatalysis – dynamic covalent chemistry – dynamic materials.

Our main research focus aims at developing abundant metal-catalyzed reactions for the formation of valuable building blocks. A panel of iron- and cobalt-catalyzed cross-coupling reactions between alkyl halides and Grignard reagents has been developed allowing the access to libraries of functionalized molecules. Besides offering an attractive alternative to expensive rare metal catalysts, the use of iron and cobalt complexes opens the way to novel reactivity. Particularly, the transient formation of radical species allows revisiting some classical radical induced rearrangements.

As ubiquitous, stable and inexpensive materials, carboxylic acids appear as ideal partners for C-C bond formation. One of our recent objectives is to develop iron-catalyzed, visible-light induced decarboxylative transformations allowing to turn simple and ideally biobased materials into functionalized building blocks.

In tight collaboration with “Chemistry and Macromolecular design”, we work on pluridisciplinary projects targeting the identification of reversible reactions that can be implemented in polymer matrixes to afford dynamic materials. Innovative vitrimers as well as self-healing injectable hydrogels are prepared and characterized.

Scientific journey

– 2018: Habilitation à diriger les recherches. “Metal-catalyzed reactions: synthetic tools towards functionalized molecules”.
– Since 2013: Maître de Conférences (assistant professor) at ESPCI Paris – Molecular, Macromolecular and Materials (C3M) – Molecular chemistry and catalysis team.
– 2013: Postdoctoral research associate at Université Paris Descartes (France) under the supervision of Dr. Laurent Micouin. “Triple bonds alumination”
– 2012: Postdoctoral research associate at Institut de Chimie Moléculaire et des matériaux d’Orsay (ICMMO, France) under the supervision of Pr. Vincent Gandon. “Gold/copper catalysis”
– 2011: Postdoctoral research associate at the Université du Québec à Montréal (Canada) under the supervision of Pr. Sylvain Canesi. “Hypervalent iodine induced phenol oxidation: application to the synthesis of natural products”.
– 2007–2010: PhD student at Sorbonne University – ESPCI Paris under the supervision of Dr. Sébastien Reymond and Pr. Janine Cossy. “Iron catalysis: methods and synthetic approach towards spirangien A”.
– 2006–2007: Master at Sorbonne Université, Paris in Organic and Bioorganic chemistry
– 2003–2007: Engineer diploma at ESPCI Paris.

Awards and distinctions

– 2011: PhD award of the French Chemical Society (Abbott-Fournier).

Selected publications

8. "Cobalt-catalyzed cross-couplings between alkyl halides and Grignard reagents". Guérinot, A.; Cossy, J. Acc. Chem. Res. 2020, 53, 1351.
7. "Copper-catalyzed cross-coupling between alkyl (pseudo)halides and bicyclopentyl Grignard reagents". Andersen, C.; Ferey, V.; Daumas, M.; Bernardelli, P.; Guérinot, A.; Cossy, J. Org. Lett. 2020, 15, 6021.
6. "Introduction of cyclopropyl and cyclobutyl ring on alkyl iodides through cobalt-catalyzed cross-coupling". Andersen, C.; Ferey, V.; Daumas, M.; Bernardelli, P.; Guérinot, A.; Cossy, J. Org. Lett. 2019, 21, 2285.
5. “Cobalt-catalyzed cross-coupling of alpha-bromo amides with Grignard reagents”. Barde, E.; Guérinot, A.; Cossy, J. Org. Lett. 2017, 19, 6068.
4. “Iron- and indium-catalyzed reactions toward nitrogen- and oxygen-containing heterocycles”. Cornil, J.; Gonnard, L.; Bensoussan, C.; Serra-Muns, A.; Gnamm, C.; Commandeur, C.; Commandeur, M.; Reymond, S.; Guérinot, A.; Cossy, J. Acc. Chem. Res. 2015, 48, 761.
3. “Cobalt-Catalyzed Cross-Coupling of 3- and 4-Iodopiperidines with Grignard Reagents”. Gonnard, L.; Guérinot, A.; Cossy, J. Chem. Eur. J. 2015, 21, 12797.
2. “Iron- and Cobalt-Catalyzed Arylation of Azetidines, Pyrrolidines, and Piperidines with Grignard reagents”. Barré, B.; Gonnard, L.; Campagne, R.; Reymond, S.; Marin, J.; Ciapetti, P.; Brellier, M.; Guérinot, A.; Cossy, J. Org. Lett. 2014, 16, 6160.
1. “Iron-catalyzed cross-coupling of alkyl halides with alkenyl Grignard reagents”. Guérinot, A.; Reymond, S.; Cossy, J. Angew. Chem. Int. Ed. 2007, 46, 6521.